Biotechnology and Bioprocess Engineering 2004; 9(4): 323-325  
Application of Modified Stokes Expression to Model the Behavior of Expanded Beds with Feed Streams Containing E. coli Homogenates
Young-Rea Chae, Yeo-Joon Yoon, and Keungarp Ryu*
School of Chemical Engineering and Bioengineering, University of Ulsan, Ulsan 680-749, Korea
© The Korean Society for Biotechnology and Bioengineering. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
To model the behavior of expanded beds with aqueous feed streams containing different amounts of glycerol, we previously developed a modified Stokes expression that correlates the terminal settling velocity of a particle of a solution with the properties of the particle (particle diameter and density) and the solution (density and viscosity). Two empirical parameters, the effective diameter of the poly-disperse resins for protein adsorption and an exponent of non-unity for (ρp-ρ)/μ term, are introduced in the modified Stokes expression. We applied the same type of the modified Stokes expression in combination with the Richardson-Zaki correlation to the published results [1], and found that the expansions of the beds with feed streams containing different amounts of E. coli homogenates can also be successfully described.
Keywords: expanded bed, modeling, Stokes expression, cell homogenates

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