Biotechnology and Bioprocess Engineering 2024; 29(5): 771-778  
Advancing biofoundry development: strategies and challenges
Aporva Gupta1,2 · Seung‑Goo Lee1,2,3 · Bong‑Hyun Sung1,2,3 · Dae‑Hee Lee1,2,3 · Byung‑Kwan Cho3,4 · Dong‑Myung Kim5 · Haseong Kim1,2,3
1 Synthetic Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea
2 Department of Biosystems and Bioengineering, Korea National University of Science and Technology, Daejeon 34113, Korea
3 Graduate School of Engineering Biology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea
4 Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea
5 Department of Chemical Engineering and Applied Chemistry, Chungnam National University, Daejeon 34134, Korea
Correspondence to: ✉ Haseong Kim
haseong@kribb.re.kr
Received: March 20, 2024; Revised: June 12, 2024; Accepted: June 17, 2024; Published online: July 2, 2024.
© The Korean Society for Biotechnology and Bioengineering. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
This study explores the development of biofoundries, emphasizing the integration of synthetic biology with artificial intelligence (AI) and robotics. It outlines critical challenges such as the necessity for interdisciplinary collaboration and the development of hardware, software, and AI specific to biofoundry operations. To address these challenges, we recommend strategies like rapid prototyping, soft integration, and the strategic implementation of AI. We underscore the vital role of synthetic biology researchers in advancing biofoundry capabilities and advocate for collaborative, multidisciplinary efforts to optimize the development and functionality of biofoundries.
Keywords: Biofoundry · Synthetic biology · Automation · Software

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