Biotechnology and Bioprocess Engineering 2024; 29(3): 427-439  
Peptides conjugation on biomaterials: chemical conjugation approaches and their promoted multifunction for biomedical applications
Jiwon Kim1 · Yonghyun Choi1,2,3 · Jongjun Park1 · Hee-Young Lee4 · Jonghoon Choi1,2
1 School of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea
2 Feynman Institute of Technology, Nanomedicine Corporation, Seoul 06974, Republic of Korea
3 Department of Chemical Science and Engineering, Tokyo Institute of Technology, 4259 Nagatsuta-Cho, Midori-Ku, Yokohama-Shi, Kanagawa 226-8503, Japan
4 Department of Chemical Engineering, Kumoh National Institute of Technology, Gumi-Si 39177, Republic of Korea
Correspondence to: Hee-Young Lee
lhysshr@kumoh.ac.kr
Jonghoon Choi
nanomed@cau.ac.kr
Received: December 29, 2023; Revised: March 11, 2024; Accepted: March 19, 2024; Published online: April 2, 2024.
© The Korean Society for Biotechnology and Bioengineering. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Researchers have made significant efforts to attach peptides to various biomaterials, resulting in diverse functionalities. By harnessing the advantages of peptides, functions such as high specificity, potency, cost-effectiveness, small size for improved tissue penetration and targeted delivery, biodegradability, and novel therapeutic applications can be achieved through their attachment to biomaterials. Of various methods available for modifying biomolecules, chemical techniques are the most established and can effectively immobilize the desired molecule onto a specific surface. This article provides a comprehensive overview of the chemical modification methods used for attaching peptides to various biomaterials in recent studies and showcases some of their latest applications.
Keywords: Peptide · Biomaterials · Chemical conjugation · Immobilization

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