Biotechnology and Bioprocess Engineering 2024; 29(2): 329-338  
Reinforced levan‑based electrospun nanofibers for application as adhesive scaffolds for tissue engineering
Young Hoon Song1 · Jeong Hyun Seo1
1 School of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Korea
Correspondence to: Jeong Hyun Seo
Received: November 19, 2023; Revised: January 29, 2024; Accepted: February 1, 2024; Published online: March 9, 2024.
© The Korean Society for Biotechnology and Bioengineering. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
The fabrication of scaffolds that mimic the structure of extracellular matrix molecules using electrospinning has great potential for various tissue engineering applications because it is advantageous for cell ingrowth and tissue formation. In particular, in the case of non-adhesive scaffolds, tissue adhesives (e.g., fibrin, glutaraldehyde) that provide strong adhesion to tissue surfaces or cells are sometimes used to efficiently utilize the desired function. Therefore, scaffolds that combine the advantages of adhesive materials while maintaining cell growth and functionality could further expand tissue engineering applications. In the present study, we developed nanofibers with greatly improved adhesive ability by blended cellulose acetate and levan, a bioadhesive polymer. Nanofibers manufactured through electrospinning exhibited stable mechanical properties through citric acid cross-linking and exhibited excellent adhesive performance with an adhesion strength of up to 3.67 MPa. In future research, we aim to expand the utility of bioadhesive nanofibers by loading nanofiber scaffolds with useful substances for diagnostic and therapeutic purposes.
Keywords: Nanofibers · Blended · Levan · Electrospinning · Adhesive · Scaffold

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