Biotechnology and Bioprocess Engineering 2024; 29(1): 165-175  
Biochemical, structural characterization and assessing the biological effects of cinnamon nanoparticles
Zahra Sabouri1 · Neda Shakour2 · Mohammad Sabouri3 · Samaneh Sadat Tabrizi Hafez Moghaddas1 · Majid Darroudi4
1 Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 9177899191, Iran
2 Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad 9177899191, Iran
3 Civil Engineering and Architecture Department, Engineering Faculty, University of Torbat Heydarieh, Torbat Heydarieh 9516168595, Iran
4 Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur 9318614139, Iran
Correspondence to: Majid Darroudi
darroudim@mums.ac.ir; majiddarroudi@gmail.com
Received: May 31, 2023; Revised: October 16, 2023; Accepted: November 19, 2023; Published online: February 13, 2024.
© The Korean Society for Biotechnology and Bioengineering. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
The natural polyphenolic materials that cinnamon contains are well known for their different biological applications and have a wide variety of pharmacological and therapeutic attributes. Bioactive and harmless cinnamon nanoparticles (cinnamon-NPs) can be anticancer and antidiabetic agents. For this purpose, water-soluble cinnamon-NPs were synthesized using the hydrothermal technique for the first time and in vitro studies were performed to investigate their anti-diabetic effects. The outcomes of morphology, size, and stability of cinnamon-NPs were described through Transmission electron microscopy (TEM), X-ray diffraction (XRD), Dynamic light scattering/Zeta (DLS/Zeta), Ultraviolet–visible (UV–Vis), and Fourier transform infrared (FTIR) analyses. The morphology of cinnamon-NPs was spherical and their average size was about 14.8 nm. Furthermore, the glucose consumption assay results revealed that compound cinnamon-NPs at 1.0 and 10 μM significantly lowered glucose levels (p < 0.05) in HepG2 cells exposed to 11.0 and 22.0 mM of glucose compared with standard (pioglitazone) and control groups. Therefore, the utilization of spherical NPs suspended in water could be useful for investigating therapeutic applications.
Keywords: Green synthesis · Cinnamon nanoparticles · Hydrothermal · Glucose · Antidiabetic activity


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