Biotechnology and Bioprocess Engineering 2024; 29(1): 1-24  
Natural products ameliorating the adverse health effects by air particulate matter
Dongyup Hahn1,2 · Min Jeong Kim1 · Yun Kwon3 · Eunjeong Kim4 · Dong Ho Park5 · Jong‑Sup Bae3
1 School of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kyungpook National University, Daegu 41566, Korea
2 Department of Integrative Biotechnology, Kyungpook National University, Daegu 41566, Korea
3 College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Korea
4 Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu 41566, Korea
5 Department of Ophthalmology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41944, Korea
Correspondence to: Jong‑Sup Bae

Dongyup Hahn and Min Jeong Kim contributed to this work equally.
Received: August 2, 2023; Revised: October 10, 2023; Accepted: November 6, 2023; Published online: February 14, 2024.
© The Korean Society for Biotechnology and Bioengineering. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
The threats of air pollution mediated by particulate matter (PM) to human health are severe burdens to modern society. For example, PM is inhaled in the lungs or affects keratinocytes to induce reactive oxygen species that exert oxidative stress, inflammatory responses, and genotoxicity. Natural products are rich sources of the antioxidant and anti-inflammatory chemicals that might counteract what PM does in the human body. This review provides a compilation of knowledge on bioactive natural products that improve the health conditions from PM-induced health outcomes. The natural products were classified according to biosynthetic origins or resources: phenolic compounds including flavonoids and other phenolics, terpenoids, steroids, phytochemicals from marine algae, statins, lipids, alkaloids, and other nitrogen-containing natural products. This review article covers the structures and biological activity of natural products investigated with tissue cells or animal models.
Keywords: Air pollution · Particulate matter · Natural products · Pulmonary diseases · Skin diseases

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