Biotechnology and Bioprocess Engineering 2023; 28(6): 892-904  
Biofoundries: Bridging Automation and Biomanufacturing in Synthetic Biology
Dae-Hee Lee, Haseong Kim, Bong-Hyun Sung, Byung Kwan Cho, and Seung-Goo Lee
Dae-Hee Lee*, Haseong Kim, Bong-Hyun Sung, Byung Kwan Cho, Seung-Goo Lee*
Synthetic Biology Research Center and the K-Biofoundry, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea
Tel: +82-42-879-8225; Fax: +82-42-860-4489
Tel: +82-42-860-4373; Fax: +82-42-860-4489
Dae-Hee Lee, Haseong Kim, Bong-Hyun Sung, Byung Kwan Cho, Seung-Goo Lee
Graduate School of Engineering Biology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea
Dae-Hee Lee
Department of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon 16419, Korea
Byung Kwan Cho
Department of Biological Sciences, KAIST, Daejeon 34141, Korea
KAIST Institutes for the BioCentury, KAIST, Daejeon 34141, Korea
Received: September 10, 2023; Revised: October 27, 2023; Accepted: October 31, 2023; Published online: December 31, 2023.
© The Korean Society for Biotechnology and Bioengineering. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Biofoundries represent advanced automation facilities pivotal for streamlining the Design-Build-Test-Learn (DBTL) paradigm in biomanufacturing and synthetic biology, suitable for both academic research and industrial applications. Nonetheless, establishing such a platform demands significant financial and temporal resources while maintaining a forward-looking perspective on automation, equipment compatibility, and operational efficiency. Despite its challenges, international collaborations between global biofoundries may offer solutions. The automated DBTL framework in biofoundries has transformed the production of bioproducts using engineered microbes. As the field advances, biofoundries are essential for streamlining and standardizing biotechnological processes, addressing efficiency, cost, and consistency challenges.
Keywords: biofoundry, DBTL cycle, synthetic biology, biomanufacturing, automation

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