Biotechnology and Bioprocess Engineering 2022; 27(3): 361-369  
Antibacterial Activity of Prenylated Flavonoids Isolated from Hop against Fish Pathogens Streptococcus iniae and Vibrio vulnificus
Mijeong Lee, Jeonghee Lee, Ja Min Kim, Dong-Hyuck Hong, Jungwook Chin, Hiyoung Kim, Joon-Goo Lee, Sang-Jip Nam, Inho Yang, and Dongyup Hahn
Mijeong Lee, Ja Min Kim, Dongyup Hahn*
School of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kyungpook National University, Daegu 41566, Korea
Tel: +82-53-950-5756; Fax: +82-53-950-6750
Jeonghee Lee, Inho Yang*
Department of Convergence Study on the Ocean Science and Technology, Korea Maritime and Ocean University, Busan 49112, Korea
Tel: +82-51-410-5398; Fax: +82-51-410-8557
Ja Min Kim, Dongyup Hahn
Institute of Agricultural Science and Technology, Kyungpook National University, Daegu 41566, Korea
Dong-Hyuck Hong
School of Bio-industrial Machinery Engineering, Kyungpook National University, Daegu 41566, Korea
Jungwook Chin
New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Korea
Hiyoung Kim
Department of Biomedical Science and Engineering, Konkuk University, Seoul 05029, Korea
Joon-Goo Lee
Department of Food Biotechnology, Dong-A University, Busan 49315, Korea
Sang-Jip Nam
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea
Dongyup Hahn
Department of Integrative Biotechnology, Kyungpook National University, Daegu 41566, Korea
Mijeong Lee and Jeonghee Lee contributed equally to this work.
Received: September 2, 2021; Revised: November 8, 2021; Accepted: November 10, 2021; Published online: June 30, 2022.
© The Korean Society for Biotechnology and Bioengineering. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Reducing fish pathogenic bacteria outbreak is important as it results in economic losses in aquaculture. Antibiotics are an inevitable tool to control the pathogenic bacteria outbreak. However, the authorities are taking more regulations to prevent the emergence of drug-resistant strain development. Alternative materials to be employed for the purpose are needed from natural sources. In this research, we explored the antibacterial activity of natural products derived from hop against fish pathogenic strains Streptococcus iniae and Vibrio vulnificus. Antimicrobial activities of nine separates from hops were tested against S. iniae and V. vulnificus and identified. Xanthohumol (1) showed strongest antibacterial property against S. iniae. In addition, desmethylxanthohumol (4) and 8-prenylnaringenin (5) showed antibacterial against both of the tested pathogen strains. Antibacterial compounds were all prenylated flavonoids, and these might be used as index components for development of feed additives for fish in aquaculture.
Keywords: Humulus lupulus L., hop, xanthohumol, desmethylxanthohumol, antibacterial activity, fish pathogen, fish farming

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