Biotechnology and Bioprocess Engineering 2022; 27(3): 295-305  
Recent Progress in Microalgal Squalene Production and Its Cosmetic Application
Çağla Yarkent and Suphi S. Oncel
Çağla Yarkent, Suphi S. Oncel*
Department of Bioengineering, Faculty of Engineering, University of Ege, Bornova 35100, Izmir, Turkey
Tel: +90-2323115812; Fax: +90-2323115880
Received: November 11, 2021; Revised: December 13, 2021; Accepted: December 15, 2021; Published online: June 30, 2022.
© The Korean Society for Biotechnology and Bioengineering. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Squalene, [oxidized form squalane] is a terpenoid with biological activity that produced by animals and plants. In the human body, a significant excretion named as sebum includes squalene in 12 percent. This bioactive compound shows anti-inflammatory, detoxifying, moisturizing and antioxidant effects on the human body. In addition to having these properties, it is known that squalene production decreases as less sebum is produced with age. Because of that, the need for supplementation of squalene through products has arisen. As a result, squalene production has been drawn attention due to its many application possibilities by cosmetic, cosmeceutical and pharmaceutical fields. At this point, approximately 3,000 of sharks, the major and the most popular source of squalene must be killed to obtain 1 ton of squalene. These animals are on the verge of extinction. This situation has caused to focus on finding microalgae strains, which are sustainable producers of squalene as alternative to sharks. This review paper summarizes the recent progresses in the topic of squalene. For this purpose, it contains information on squalene producers, microalgal squalene production and cosmetic evaluation of squalene.
Keywords: squalene, microalgae, microalgal process, bioactive compound, cosmetics

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