Biotechnology and Bioprocess Engineering 2021; 26(6): 871-886  
Progress in Preparation of Cellulase from Lignocellulose Using Fungi
Hui Jiao, Xiangyang Song, Chenhuan Lai, Hao Fang, Yuqi Song, and Junjun Zhu
Hui Jiao, Xiangyang Song*, Chenhuan Lai, Yuqi Song, Junjun Zhu
College of Chemical Engineering, Nanjing Forestry University, Nanjing, Jiangsu 210037, China
Tel/Fax: +86-025-85427587
Hao Fang
College of Life Sciences, Northwest Agricultural and Forestry University, Yangling, Shaanxi 712100, China
Yuqi Song
Department of Civil Engineering, Monash University, Melbourne 3800, Australia
Received: September 8, 2020; Revised: December 10, 2020; Accepted: December 12, 2020; Published online: December 31, 2021.
© The Korean Society for Biotechnology and Bioengineering. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Lignocellulosic biomass such as agricultural and forestry waste is the most abundant renewable organic carbon source on earth and can be used to produce source of clean energy such as ethanol. One of the disadvantages of the preparation of ethanol using lignocellulose as raw material is the high cost of production of cellulase. Fungi are capable of effectively degrading lignocellulose and secreting a large amount of cellulase, and have the advantages of ease of preparation, high yield, and full enzyme systems. Therefore, this paper reviews sources of lignocellulose and the biodegradation properties which limit the production of cellulase, proposes micro-organisms capable of degrading lignocellulose and explains the types of cellulase, and the mechanism of action, methods of fermentation optimization, and control are analyzed, and ways to increase the yield of cellulase are described. Finally, research on the effects of inducers on the production of cellulase by fungi is reviewed. The aims of this review are to provide a reference for the efficient production and industrial application of cellulase.
Keywords: cellulase, lignocellulose, surfactant, liquid fermentation, inducer, fungi

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