Biotechnology and Bioprocess Engineering 2021; 26(4): 606-611  
Characterization and Anti-inflammatory Effects of Gamma-irradiation on Undaria pinnatifida Root Water Extracts
Xiaotong Xu, So-Mi Jeong, Ji-Eun Lee, Woo-Sin Kang, Si-Hyeong Ryu, Eui-Baek Byun, Kwangwook Kim, Eui-Hong Byun, and Dong-Hyun Ahn
Xiaotong Xu, Ji-Eun Lee, Woo-Sin Kang, Si-Hyeong Ryu, Dong-Hyun Ahn *
Department of Food Science and Technology, Pukyong National University, Busan 48513, Korea
Tel: +82-51-629-5831; Fax: +82-51-629-5824
E-mail: dhahn@pknu.ac.kr
So-Mi Jeong
Institute of Fisheries Sciences, Pukyong National University, Busan 46041, Korea
Eui-Baek Byun
Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup 56212, Korea
Kwangwook Kim, Eui-Hong Byun
Department of Food Science & Technology, Kongju National University, Yesan 32439, Korea
Received: October 5, 2020; Revised: February 23, 2021; Accepted: February 27, 2021; Published online: August 30, 2021.
© The Korean Society for Biotechnology and Bioengineering. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
In this study, characterization and anti-inflammatory activity of Undaria pinnatifida root (UPR) water extracts treated by gamma (γ)-irradiation were investigated. The UPR powder was dissolved in distilled water to form UPR water extracts. Subsequently, they were irradiated with cobalt-60 γ-rays in a dose range from 3 to 20 kGy. In the reducing sugar and viscosity analyses, the reducing sugar content showed a two-fold increase at 20 kGy compared to the non-irradiated control, and UPR water extracts viscosity decreased with increasing irradiation dose. Using thin-layer chromatography (TLC), UPR polysaccharides were degraded to monosaccharides after γ-irradiation treatment. Moreover, UPR water extracts treated with γ-irradiation inhibited the production of nitric oxide (NO) and pro-inflammatory cytokine (IL-6 and TNF-α) activity. Therefore, γ-irradiation not only degrades UPR water extracts polysaccharides, but also increases the antiinflammatory activity of UPR water extracts.
Keywords: anti-inflammatory effect, degradation, Undaria pinnatifida root, γ-irradiation, polysaccharides


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