Biotechnology and Bioprocess Engineering 2021; 26(4): 575-585  
Anti-obesity Potential of Lactobacillus spp. Isolated from Infant Feces
Hyemin Kim, Yulah Jeong, Ji-Eun Kim, YongGyong Kim, Nam-Soo Paek, and Chang-Ho Kang
Hyemin Kim, Yulah Jeong, Ji-Eun Kim, YongGyong Kim, Nam-Soo Paek, Chang-Ho Kang*
MEDIOGEN Co., Ltd., Jecheon 27159, Korea
Tel: +82-43-842-1940; Fax: +82-43-842-1944
E-mail: changho-kang@naver.com
Received: September 17, 2020; Revised: November 23, 2020; Accepted: November 25, 2020; Published online: August 30, 2021.
© The Korean Society for Biotechnology and Bioengineering. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Obesity is fast becoming a worldwide health concern and causes a chronic state of oxidative stress and low-grade inflammation, which could be major risk factors for a number of chronic diseases. We investigated the potential of the 61 probiotic candidates isolated from infant feces towards activity of lipid accumulation inhibition, and then we extended the study to evaluate their antidiabetic and antioxidant activity. Seven strains were finally selected based on their ability to inhibit lipid accumulation (> 60%) and productivity yield (> 1 × 1011 colony forming units [CFU]/g): Lactobacillus acidophilus MG4558; Lactobacillus paracasei MG4592; Lactobacillus plantarum MG4553 and MG4555; and Lactobacillus rhamnosus MG4502, MG4511, and MG4505. Selected strains showed high α-glucosidase-inhibiting activity (> 50%), except for MG4511 (19.8%), and similar antioxidant activities were reflected by the results of DPPH (21.6-27.5%) and ABTS (40.9-44.9%) assays. With respect to their functional properties as probiotics, most of the strains were resistant to simulated gastric (pH 3 and 4) and intestinal (pH 7 and 8) fluids, and possessed various probiotic-related factors, including autoaggregation ability, antibiotic susceptibility, enzyme production, and biochemical profiles, and were non-hemolytic. We conclude that our strains may be good probiotic candidates for functional food ingredients to prevent metabolic disorders such as obesity and diabetes.
Keywords: anti-obesity, antidiabetic, antioxidant, probiotics, Lactobacillus


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