Biotechnology and Bioprocess Engineering 2021; 26(4): 529-545  
Nanostructure Materials: Efficient Strategies for Circulating Tumor Cells Capture, Release, and Detection
Sahar Asghari, Fatemeh Barati, Manizheh Avatefi, and Matin Mahmoudifard
Sahar Asghari, Fatemeh Barati, Manizheh Avatefi, Matin Mahmoudifard*
Department of Industrial and Environmental Biotechnology, National
Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran 14965/161, Iran
Tel: +98-9126355760
Received: August 11, 2020; Revised: October 5, 2020; Accepted: October 14, 2020; Published online: August 30, 2021.
© The Korean Society for Biotechnology and Bioengineering. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
It has been proved that most of the deaths due to cancer are related to metastasis. This process occurs through the separation of cells from the primary tumor and maintenance in the circulation systems in the body. Finally, if the condition for the relocalizing of them in other sites becomes appropriate, they produce new tumors in various parts of the body. The number of these circulating tumor cells (CTCs) in the blood is very rare. So, detecting and counting them is difficult, but very vital. There are various techniques for the detection of CTCs, which along with them, nanomaterials are suitable tools for this purpose due to their small sizes and unique properties. Because of the high efficiency of these materials, it is possible to exceed the other mentioned methods. In this review, we aim to render a comprehensive study about recent advances in the capture and subsequent release of the CTCs using different types of nanomaterials.
Keywords: CTC, nanomaterials, capture, release, detection

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