Biotechnology and Bioprocess Engineering 2021; 26(4): 503-516  
Hyaluronic Acid-based Biomimetic Hydrogels for Tissue Engineering and Medical Applications
Soohwan An, Soojeong Choi, Sungjin Min, and Seung-Woo Cho
Soohwan An, Soojeong Choi, Sungjin Min, Seung-Woo Cho*
Department of Biotechnology, Yonsei University, Seoul 03722, Korea
Tel: +82-2-2123-5662
These authors contributed equally to this work.
Received: October 25, 2020; Revised: January 12, 2021; Accepted: January 13, 2021; Published online: August 30, 2021.
© The Korean Society for Biotechnology and Bioengineering. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Hyaluronic acid (HA), an essential component of extracellular matrix (ECM), plays an important role in various cellular activities, including migration, proliferation, and differentiation. Not only its structural and biological properties, but also properties such as biocompatibility, biodegradability, and low immunogenicity make HA a promising biomaterial for tissue engineering and regenerative medicine. HA has been widely utilized as a hydrogel to form complex polymer networks, which can be chemically modified owing to the abundance of functional groups. To closely recapitulate native tissues, many approaches have been developed through chemical modification, incorporation of various biomaterials and biomolecules based on biomimetics, and fabrication techniques. Thus, HA-based hydrogels can be designed to exhibit specific properties or functions for targeted tissues, capable of maintaining or replacing structural and biological properties. This review highlights recent efforts in developing HA-based hydrogels as ECM-mimetic scaffolds and bio-inspired functional biomaterials in the fields of tissue engineering and regenerative medicine as well as their medical applications.
Keywords: hyaluronic acid, biomimetic hydrogel, tissue engineering, biomedical applications

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