Biotechnology and Bioprocess Engineering 2021; 26(1): 71-77  
Alginate-chitosan Hydrogel Patch with Beta-glucan Nanoemulsion for Antibacterial Applications
Yonghyun Choi, Jaehee Jang, Hyung-Jun Koo, Masayoshi Tanaka, Keun-Heon Lee, and Jonghoon Choi
Yonghyun Choi, Jaehee Jang, Jonghoon Choi*
School of Integrative Engineering, Chung-Ang University, Seoul 06974, Korea
Tel: +82-2-820-5258
Hyung-Jun Koo
Department of Chemical and Biomolecular Engineering, Seoul National University of Science and Technology, Seoul 01811, Korea
Masayoshi Tanaka
Department of Chemical Science and Engineering, Tokyo Institute of Technology, 2-12-1-S1-24, O-okayama, Meguro-ku, Tokyo 152-8552, Japan
Keun-Heon Lee
Humas, Daejeon 34224, Korea
Received: June 15, 2020; Revised: July 15, 2020; Accepted: July 15, 2020; Published online: February 28, 2021.
© The Korean Society for Biotechnology and Bioengineering. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Natural polymer materials have high biocompatibility and are not toxic because they can decompose into metabolites in the body; thus, they are widely used as medical polymer materials as well as porous support materials. As a biopolymer, alginate has a negative charge; in contrast, chitosan has a positive charge. Therefore, when the two substances are mixed, they form a relatively stable structure by ionic bonding. Beta-glucan is known to contribute to material stability and have high skin penetration, skin moisturizing and soothing effects, and burn and wound healing effects. In this study, antimicrobial activity was assessed by preparing alginate-chitosan hydrogel patches containing beta-glucan nanoemulsions. This could contribute to the development of wound dressings with antibacterial properties.
Keywords: beta-glucan, biopolymer, alginate, chitosan, antibacterial

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