Biotechnology and Bioprocess Engineering 2021; 26(1): 1-9  
A Novel Strategy for the Microbial Removal of Heavy Metals: Cell-surface Display of Peptides
Yuanyuan Wang, Vidhya Selvamani, Ik-Keun Yoo, Tae Wan Kim, and Soon Ho Hong
Yuanyuan Wang, Vidhya Selvamani, Ik-Keun Yoo, Soon Ho Hong*
Department of Chemical Engineering, University of Ulsan, Ulsan 44610,Korea
Tel: +82-52-259-1293; Fax: +82-52-259-2247
Yuanyuan Wang
College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China
Tae Wan Kim*
Department of Biotechnology & Bioengineering, Chonnam National University, Gwangju 61186, Korea
Tel: +82-62-530-1842; Fax: +82-62-530-1949
Received: July 9, 2020; Revised: September 7, 2020; Accepted: September 9, 2020; Published online: February 28, 2021.
© The Korean Society for Biotechnology and Bioengineering. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Cell surface engineering is a rapidly developing technology of microorganism that achieves modification of cell surface function by joining external functional peptides with surface anchoring proteins, for example, Outer Member Protein (OMP). On account of these proteins possessing metal responsive motifs, they can be specifically used for metal adsorption and dissociation. To elucidate the problems caused by heavy metals and develop various technologies for their removel or recovery, various metalbinding proteins/peptides fused on microorganism cell surface have been applied as novel methods. During the past few years, bacterial cell surface display strategy has received growing attention for their availability to eliminate heavy metals. In this paper, the existing problems, progress, and suggestions for furture of the peptide displaying system are summarized.
Keywords: wastewater treatment, biosorption, cell-surface display, bacteria, yeast, algae

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