Biotechnology and Bioprocess Engineering 2020; 25(6): 848-861  
Recent Advances in Systems Metabolic Engineering Strategies for the Production of Biopolymers
Yu Jung Sohn, Hee Taek Kim, Seo Young Jo, Hye Min Song, Kei-Anne Baritugo, Jiwon Pyo, Jong-il Choi, Jeong Chan Joo, and Si Jae Park
Yu Jung Sohn†, Seo Young Jo, Hye Min Song, Kei-Anne Baritugo, Jiwon Pyo, Si Jae Park*
Division of Chemical Engineering and Materials Science, System Health & Engineering Major in Graduate School (BK21 Plus Program), Ewha Womans University, Seoul 03760, Korea
Tel: +82-2-3277-4756; Fax: +82-2-3277-3275
E-mail: parksj93@ewha.ac.kr
Hee Taek Kim†
Research Center for Bio-based Chemicals, Korea Research Institute of Chemical Technology Daejeon 34114 & Ulsan 44429, Korea
Jong-il Choi
Department of Biotechnology and Bioengineering, Chonnam National University, Gwangju 61186, Korea
Jeong Chan Joo*
Department of Biotechnology, The Catholic University of Korea, Bucheon 14662, Korea
E-mail: jcjoo@catholic.ac.kr
†These authors contributed equally to this work.
Received: December 30, 2019; Revised: March 16, 2020; Accepted: March 18, 2020; Published online: December 31, 2020.
© The Korean Society for Biotechnology and Bioengineering. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Biopolymers consisting of at least one monomer, which are produced from renewable carbon sources, are being highly sought out since ubiquitous plastics are mainly produced from petrochemical processes causing severe environmental pollution. Therefore, the development of microbial cell factories, which can efficiently synthesize diverse types of monomers and polymers, is also becoming increasingly important. The applicability of traditional metabolic engineering strategies has extended with the combination of systems biology, synthetic biology, and evolutionary engineering in a systemic and versatile manner, and are collectively termed as systems metabolic engineering. Accordingly, recent advances in biotechnology have paved the way for enabling the production of an increasing number of monomers and polymers by providing several tools and strategies associated with systems metabolic engineering. In this review, we have focused on the substantial efforts made on the development of different approaches of systems metabolic engineering, particularly based on synthetic biology and evolutionary engineering, for the efficient production of monomers and polymers.
Keywords: biopolymers, metabolic engineering, systems metabolic engineering, synthetic biology, evolutionary engineering

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