Biotechnology and Bioprocess Engineering 2020; 25(6): 829-847  
Metabolic Engineering and Synthetic Biology of Cyanobacteria for Carbon Capture and Utilization
Napisa Pattharaprachayakul, Jong-il Choi, Aran Incharoensakdi, and Han Min Woo
Napisa Pattharaprachayakul, Han Min Woo*
Department of Food Science and Biotechnology, Sungkyunkwan University (SKKU), Suwon 16419, Korea
Tel: +82-31-290-7808; Fax: +82-31-290-7882
Napisa Pattharaprachayakul
Program in Biotechnology, Faculty of Science, Chulalongkorn University, 254 Phayathai Road, Pathumwan, Bangkok 10330, Thailand
Jong-il Choi
Department of Biotechnology and Bioengineering, Chonnam National University, Gwangju 61186, Korea
Napisa Pattharaprachayakul, Aran Incharoensakdi
Laboratory of Cyanobacterial Biotechnology, Department of Biochemistry, Faculty of Science, Chulalongkorn University, 254 Phayathai Road, Pathumwan, Bangkok 10330, Thailand
Han Min Woo
BioFoundry Research Center, Institute of Biotechnology and Bioengineering, Sungkyunkwan University (SKKU), Suwon 16419, Korea
Received: December 6, 2019; Revised: January 28, 2020; Accepted: February 1, 2020; Published online: December 31, 2020.
© The Korean Society for Biotechnology and Bioengineering. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Cyanobacteria are photosynthetic bacteria that can directly convert CO2 into several bio-products for industrial use, such as alcohols and diols, terpenes, acids, and sugars. However, some of these compounds are either produced in low amounts or are absent in cyanobacteria, and thus strain development is required to achieve optimal production of these bio-products for industrial applications. Metabolic engineering has been applied to modify cyanobacteria for enhanced production of value-added compounds. In this review, we have elucidated metabolic engineering of various pathways with the yield and productivity of the desired products. We have also described recent overall strategies in advanced metabolic engineering.
Keywords: cyanobacteria, metabolic engineering, synthetic biology, carbon capture and utilization

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