Biotechnology and Bioprocess Engineering 2020; 25(6): 810-828  
Recent Advances in Microbial Cell Growth Regulation Strategies for Metabolic Engineering
Myung Hyun Noh, Sanghak Cha, Minsun Kim, and Gyoo Yeol Jung
Myung Hyun Noh†, Sanghak Cha†, Gyoo Yeol Jung*
Department of Chemical Engineering, Pohang University of Science and Technology, Pohang 37673, Korea
Tel: +82-54-279-2391; Fax: +82-54-279-5528
E-mail: gyjung@postech.ac.kr
Minsun Kim, Gyoo Yeol Jung
School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang 37673, Korea
†These authors contributed equally to this work.
Received: December 30, 2019; Revised: April 9, 2020; Accepted: April 11, 2020; Published online: December 31, 2020.
© The Korean Society for Biotechnology and Bioengineering. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Programming a new function into cells and balancing new functions with native cellular metabolism or program related to cell growth have long been a challenge in metabolic engineering. In this regard, advances in synthetic biology and systems biology have broadly expanded the cell growth control strategies, empowering the strategies to be applied in metabolic engineering more effectively. In this review, we describe the advances and perspectives in cell growth control strategies. First, the strategies to utilize the environmental stress was described. Second, the strategies to precisely regulate the central metabolism and to exploit the cellular programs were summarized. Third, strategies related to evolutionary engineering, which have evolved significantly, including the emergence of new types of screening devices, have been summarized. Lastly, we described the strategies through exploiting new systems that are being actively applied in metabolic engineering. We hope that our review can provide enough information and perspectives in growth control strategies.
Keywords: metabolic engineering, synthetic biology, systems biology, cell growth control

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