Biotechnology and Bioprocess Engineering 2020; 25(1): 16-21  
Anti-inflammatory Effects of Sargachromanol I, Sargachromanol G, and Saringosterol from Hexane Fraction of Myagropsis myagroides
Koth-Bong-Woo-Ri Kim1, So-Mi Jeong1, Da-Hyun Jeong2, Min-Ji Kim2, and Dong-Hyun Ahn2,*
1Institute of Fisheries Sciences, Pukyong National University, Busan 46041, Korea
2Department of Food Science & Technology/Institute of Food Science, Pukyong National University, Busan 48513, Korea
Correspondence to: Dong-Hyun Ahn*
Department of Food Science & Technology/Institute of Food Science, Pukyong National University, Busan 48513, Korea
Tel: +82-51-629-5831; Fax: +82-51-629-5824
E-mail: dhahn@pknu.ac.kr
Received: July 11, 2019; Revised: October 22, 2019; Accepted: November 9, 2019; Published online: February 29, 2020.
© The Korean Society for Biotechnology and Bioengineering. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
The anti-inflammatory activity of benzopyran derivatives extracted from the Myagropsis myagroides against lipopolysaccharide (LPS)-induced RAW 264.7 murine macrophage cell line was examined. The three constituents of M. myagroides extracts were identified as the sargachromanol G, sargachromanol I, and saringosterol by 1H and 13C NMR. Sargachromanol G, sargachromanol I, and saringosterol at concentrations of 50 µg/mL showed inhibitory effects on LPS induced interleukin-6 production (by 84%, 90%, and 96%, respectively) and tumor necrosis factor (by 74%, 82%, and 98%, respectively). These results confirm the potential anti-inflammatory effects of sargachromanol G, sargachromanol I, and saringosterol.
Keywords: anti-inflammatory effect, Myagropsis myagroides, sargachromanol G, sargachromanol I, saringosterol


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