Biotechnology and Bioprocess Engineering 2019; 24(3): 560-567  
6-shogaol a Active Component from Ginger Inhibits Cell Proliferation and Induces Apoptosis through Inhibition of STAT-3 Translocation in Ovarian Cancer Cell Lines (A2780)
Ting Liang1, Ying He2, Yuhua Chang3, and Xiantong Liu3,*
1Biomedical Isotope Research Center,School of Basic Medical Sciences, Shandong University, Jinan, Shandong Shandong 250012, China
2Department of Gynaecology and Obstetrics, Feixian People’s Hospital, Linyi, Shandong 5221030, China
3Maternal and Child Health Care of Shandong Province, Jinan, Shandong 250014, China
Correspondence to: Xiantong Liu
Tel: +8615589905577
E-mail: sdliuxiantong@sina.com
Received: December 29, 2018; Revised: March 8, 2019; Accepted: March 10, 2019; Published online: June 30, 2019.
© The Korean Society for Biotechnology and Bioengineering. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Ovarian cancer is predominant form of malignant which occupies 70 % cancer in women worldwide. Taxals, anthrocyclins and platinum based drugs are used as chemotherapeutic for treatment of ovarian cancer. These drugs were limited by drug resistance and it produces several toxicity. Therefore, we used natural drug which inhibits the cancer cell growth by modulating specific molecular mechanisms. This study, we evaluated the 6-shogaol a active component from ginger inhibits cell proliferation by modulation of JAK/STAT-3 signalling in ovarian cancer cell lines (A2780). In this study, we found that 6-shogaol induces cytotoxicity, ROS production and apoptosis in A2780 cell lines by time depending manner. Moreover, signal transducer and activating transcription-3 (STAT-3) has been consider as novel transcriptional factor which regulates apoptosis, cell proliferation and angiogensis. Inhibition of STAT-3 transcription considered as novel strategy to inhibiting ovarian cell growth. In this study, we found that 6-shogaol inhibits STAT-3 translocation there by inhibits the over expression of PCNA, cyclin-D1, Bcl-2 and decreased expression of Bax, caspase-9 and 3 in A2780 cell lines. This results concluded that 6-shogaol inhibits ovarian cell growth and induces apoptosis through inhibits the translocation STAT-3.
Keywords: 6-shogaol, ovarian cancer, apoptosis, STAT-3


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