Biotechnology and Bioprocess Engineering 2019; 24(3): 529-535  
Characteristics and Mechanism of Microwave-assisted Drying of Amorphous Paclitaxel for Removal of Residual Solvent
Won-Seok Jang and Jin-Hyun Kim*
Department of Chemical Engineering, Kongju National University, Cheonan 330-717, Korea
Correspondence to: Jin-Hyun Kim
Tel: +82-41-521-9361; Fax: +82-41-554-2640
E-mail: jinhyun@kongju.ac.kr
Received: February 24, 2019; Revised: March 24, 2019; Accepted: April 1, 2019; Published online: June 30, 2019.
© The Korean Society for Biotechnology and Bioengineering. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
We investigated the characteristics and mechanism of microwave-assisted drying of amorphous paclitaxel for the removal of residual solvent, acetonitrile. The removal efficiency of residual acetonitrile increased with increasing drying temperature from 35 to 55°C. When the experimental data were applied to typical kinetic models, the Page model was determined to be the most suitable. Thermodynamic parameters revealed the spontaneous and endothermic nature of microwave-assisted drying. The effective diffusion coefficient of acetonitrile (0.865 × 10-8~1.553 × 10-8m2/s) and the convective mass transfer coefficient (2.138 × 10-7~7.656 × 10-7 m/s) increased with increasing drying temperature. The small Biot number (0.001975~0.003939) indicated that the process of mass transfer was externally controlled.
Keywords: amorphous paclitaxel, microwave-assisted drying, characteristics, effective diffusivity, mass transfer coefficient


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