Biotechnology and Bioprocess Engineering 2019; 24(3): 483-487  
Complete Genome Sequence of Lactic Acid Bacterium Pediococcus acidilactici Strain ATCC 8042, an Autolytic Anti-bacterial Peptidoglycan Hydrolase Producer
Sung Won Cho1,†, Jina Yang2,†, Sungwoo Park1, Beomhee Kim1, and Sang Woo Seo1,2,*
1School of Chemical and Biological Engineering, Seoul National University, Seoul 08826, Korea
2Institute of Chemical Process, Seoul National University, Seoul 08826, Korea
Correspondence to: Sang Woo Seo
Tel: +82-2-880-2274; Fax: +82-2-888-7295

These authors contributed equally to this work.
Received: January 31, 2019; Revised: April 2, 2019; Accepted: April 15, 2019; Published online: June 30, 2019.
© The Korean Society for Biotechnology and Bioengineering. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Pediococcus acidilactici is a probiotic bacterium that is industrially utilized in the food industry and antibiotics development. Here, we determine the complete nucleotide sequence of the genome of Pediococcus acidilactici ATCC 8042. The genome was sequenced by the PacBio RSII to generate a single contig consisting of circular chromosome sequence. Illumina MiniSeq sequencing platform and Sanger sequencing method were additionally utilized to correct errors resulting from the long-read sequencing platform. The sequence consists of 2,009,598 bp with a G + C content of 42.1% and contains 1,865 protein-coding sequences. Based on the sequence information, we could confirm and predict the presence of four peptidoglycan hydrolases by HyPe software. This work, therefore, provides the complete genomic information of P. acidilactici ATCC 8042 with a profitable potential of genome-scale comprehension of anti-pathogenic activity, which can be applied in nutraceutical and pharmaceutical biotechnology field.
Keywords: Pediococcus acidilactici ATCC 8042, complete genome sequence, peptidoglycan hydrolase, antimicrobial activity

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